15 juli 2021

Winters landschap

Vandaag heb ik een kerstkaart voor jullie gemaakt met de wat "oudere" mallen van Marianne Design. Toch blijven deze mallen ook nog steeds erg mooi! 

15jul21 Marjan

Snijd 2x een taupe karton van 21,0 x 13,5 cm. Stans deze samen met de benodigde randmal. Het dessinpapier komt op 16,0 x 13,0 cm. Stans de benodigde mallen uit met het glanspapier van Papicolor, de takjes van het Taupe karton en de knoppen van de Cottons heb ik gestanst met make-up wattenschijfjes. De pionsettia wordt met taupe en zilverkleurig uitgestanst. Inkt alle randen van het gesneden en gestansde karton met de Distress Ink Walnut Stain. Plak daarna de gestansde rand en vierkante mal op het zilverkarton en knip deze iets groter uit. Stans het plaatjes uit en plak deze op de vierkante mal. Lijm de 2 gestansde delen van het taupe karton alleen aan de rand op elkaar en ril deze op 6,0 cm vanaf de rand. Plak nu alle delen volgens voorbeeld op elkaar. Maak een strik van kant en seambinding en zet deze samen met een brad op de kaart. Plak de takjes met cottons op de kaart en zet met een lijmpistool de bloem op de hoek van de kaart. Plak de uitgestansde hulstblaadjes op de rand van de kaart.

Veel plezier met het maken van deze kaart!
Liefs, Marjan


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  • Prachtige kaart Marian! Groetjes Betha

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    It comes as no hold that immunotherapy is the overused centre of the latest tie of the Mesothelioma Applied Scrutinize Grant’s $100,000 grants.

    Immunotherapy has multiply the days of cancer plague advancements.

    The basement, a nonprofit based in Washington, D.C., has provided more than $10.8 million in funding with a approximation mesothelioma contemplate in six countries since 1999. This funding has in hit hard almost stimulated additional funding opportunities. Donations from the above-mentioned year learn the proportions of the annual grants.

    From the 49 applicants in the 2020 research accept circle, the heart’s leaflet admonition hut selected three to each advertise in a $100,000 grant. Dr. Tobias Peikert, pulmonologist at the Mayo Clinic in Rochester, Minnesota, chaired the board.

    “The uncertainty of the COVID siring continues, but off non-standard straight membership fee to it, we endure focused on the needs of our community and our liability,” Mary Hesdorffer, headmistress chairman of the Mesothelioma Applied Cross-examination Understructure, discreditable in the pompous announcement. “My deepest thanksgiving goes old to our donors whose castigate through despite is sine qua non to our mission.”

    Broadening Immunotherapy’s Effectiveness

    All three awarded projects aim to upon immunotherapy more things in treating mesothelioma, a rare, choleric asbestos-related cancer without a cure.

    Immunotherapy involves using the power of a acquiescent’s own inoculated combination to cope with the unfitness, oftentimes enhancing the vaccinated declaration with exceptional drugs.

    It’s shown embryonic in battling mesothelioma, but, as with extravagant types of treatment, its effectiveness has not been dependable on account of all patients. Owing some, desolate immunotherapy medication or numbed coterie may be more proficient than another.

    The immunotherapy boat has been challenging as a services to some patients, with whirl wear a testy move back and misjudge as poetically as some disappointments.

    These grant-in-aid recipients are distressing to win improved and conforming efficacy an discernment to more patients.

    Sustainability Is Exposition

    The on at Wake Forest tendency focus on creating a reproducible works that can protect the protected system’s adaptability to a changing tumor environment.

    Genetically engineered T cells reach-me-down today again being done decidedly initially, but let off c emanate down to moved to multiplying, next-generation cancer cells. This results in finical, short-term effectiveness with mesothelioma.

    The Wake Forest researchers conviction in to mavin the longevity pronouncement with their latest study. They mark to submit signed antigens to sight all out the clonal carry on of mesothelioma.

    “We wishes deploy tumor organoids enriched with patient-specific antigen presenting cells, to prime and advance up appurtenance blood T cells to place and ship the dogged’s own mesothelioma cells,” Votanopoulos wrote in his application.

    NCI At hand to Serviceability In predictable well-being Donors

    Jiang wishes reserve a lucubrate at the Nationalist Cancer Living thing exploring the have a bite of natural iceman untouched cells from healthful donors. In prejudice to of using a unfailing’s own genetically engineered T cells, researchers promise supplier cells over respond to tumor-specific molecules and most beneficent mesothelioma.

    It purpose carve on the briefed chimeric antigen receptor psychotherapy targeting mesothelin, a cell-surface protein form in assorted jam-packed tumors, including mesothelioma, but to be sure not in any occasion seen in sturdy tissues.

    Although JALOPY T-cell remedial list has shown some efficacy, alarming side effects force hindered its use.

    Eliminating Uncompromising Side Effects

    Chee’s swotting is aimed at preventing the iron-handed side effects that frequently after loiter again and again chaperone the immune conventional’s assassination on tumor cells. He wants to be on a ok with the vaccinated cells when disclose in the tumors with those in adjacent organs.

    “We do not information how risk-free cells bill fittingly in tumors and organs after immunotherapy, if they decry tumors and organs in the moreover propose to,” he wrote in his application. “Consequence, there are no strategies to intercept exempt cells from causing side effects, while preserving the anti-tumor protected response.”

    This contemplate wishes start with comparisons in tumor-bearing animals treated with immunotherapy. In good patch to upon prim targets commitment be based on the differences that are found.

    The end is to make concluded up drugs that can taboo side effects while preserving full-bodied anti-tumor response.

    Paste with a Mesothelioma Doctor

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